However, symptoms remain in a proportion of people and the studies have many limitations. Nevertheless, cetirizine 20 mg appears to be well tolerated and the benefits may outweigh the risks for some people whose quality of life is significantly impaired by the condition. No data are available from high quality studies on the use of cetirizine at doses higher than 20 mg.
Regulatory status: Cetirizine is licensed for the relief of symptoms of chronic idiopathic urticaria at a dose of 10 mg daily in adults. The use of higher doses of cetirizine, as discussed in this evidence summary, is off-label. Four small studies suggest that cetirizine 20 mg daily may improve symptoms in adults with severe chronic urticaria.
In Okubo et al , itching and weals improved in people who took cetirizine 20 mg daily or olopatadine 5 mg twice daily as a dose increase from cetirizine 10 mg. According to the summaries of product characteristics for example, Zirtek , cetirizine 10 mg daily has minor central nervous system adverse effects including somnolence, fatigue, dizziness and dry mouth.
Chronic urticaria can significantly reduce quality of life and is sometimes refractory to standard treatment. From the limited evidence available, cetirizine 20 mg appears to be well tolerated. Some people may be prepared to risk adverse effects such as drowsiness in order to reduce symptoms.
Urticaria is a superficial swelling of the skin that results in a red, raised, itchy rash weals. Acute urticaria may be caused by allergy to foods, drugs, irritants, insect bites and stings, physical stimuli and viral infection. It is usually a self-limiting, one-off episode. By contrast, the cause of many cases of chronic urticaria cannot be identified and it may remit and relapse, triggered by, for example, viral illness, stress, or drugs.
In chronic urticaria, symptoms last for more than 6 weeks recurrence of acute symptoms or persistent symptoms and may last for months or years NICE Clinical knowledge summary: urticaria. Click send to recieve an email with instructions on how to create your new password.
Use only as directed. Buy Online Find Locally. Relieves your worst allergy symptoms, indoors and out. This website contains current product information and may differ from the information on the product packaging you may have. Why Zyrtec. Where to Buy. Temporarily relieves these symptoms due to hay fever or other upper respiratory allergies: Runny nose Sneezing Itchy, watery eyes Itching of the nose or throat.
When using this product: drowsiness may occur avoid alcoholic drinks alcohol, sedatives and tranquilizers may increase drowsiness be careful when driving a motor vehicle or operating machinery Stop use and ask a doctor if an allergic reaction to this product occurs.
If pregnant or breast-feeding: if breast-feeding: Not recommended if pregnant: Ask a health professional before use Keep out of reach of children. Adults 65 years and over: Ask a doctor. If you do not have a syringe or spoon, ask your pharmacist for one. Do not use a kitchen teaspoon as it will not measure out the right amount. You may only need to take cetirizine on a day you have symptoms — for example, if you have been in contact with something that has triggered your allergy, like animal hair.
Or you may need to take it regularly to prevent symptoms — for example, to stop hay fever during spring and summer. Take your forgotten dose as soon as you remember, unless it's nearly time for your next dose. In this case, skip the missed dose and take your next dose at the usual time. If you forget to give a dose to a child who is taking cetirizine twice a day, you can give the missed dose if it's within 4 hours of when they should have had it.
If you remember more than 4 hours after, do not give the missed dose. Instead, wait until the next dose and carry on as normal.
If you often forget doses, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine. Cetirizine is generally very safe. Taking more than the usual dose is unlikely to harm you or your child. If you take an extra dose, you might get some of the common side effects. If this happens or you're concerned, contact your doctor. Like all medicines, cetirizine can cause side effects, although not everyone gets them.
The most common side effect of cetirizine is feeling sleepy and tired. This happens in more than 1 in 10 people. Talk to your doctor or pharmacist if this side effect bothers you or does not go away. Other common side effects of cetirizine happen in more than 1 in people.
Talk to your doctor or pharmacist if these side effects bother you or do not go away:. Children are more likely to get diarrhoea, sneezing or a blocked and runny nose than adults. Call your doctor straight away if you have bruising or bleeding that's more than normal. In rare cases, it's possible to have a serious allergic reaction anaphylaxis to cetirizine. These are not all the side effects of cetirizine. For a full list, see the leaflet inside your medicines packet. Cetirizine can be used in pregnancy.
There is no good evidence that it causes harm to the baby. However, other antihistamines such as loratadine may be recommended as there is more information about its use in pregnancy. If your doctor or health visitor says your baby is healthy, you can take cetirizine while breastfeeding. There is some information available which shows that only very small amounts get into breast milk. Cetirizine has been used for many years while breastfeeding without side effects in babies.
If your baby is not feeding as well as usual, seems unusually sleepy, or if you have any other concerns about your baby, talk to your doctor, pharmacist, health visitor or midwife. Some medicines can increase the chances of you having side effects with cetirizine. Check with your pharmacist or doctor if you're taking any medicine that makes you drowsy, gives you a dry mouth, or makes it difficult for you to pee.
Taking cetirizine might make these side effects worse. There might be a problem taking some herbal remedies and supplements alongside cetirizine, especially ones that cause sleepiness, a dry mouth, or make it difficult to pee. Tell your doctor or pharmacist if you're taking any other medicines, including herbal medicines, vitamins or supplements. Cetirizine is a type of medicine called an antihistamine.
When you come into contact with something you're allergic to, such as pollen, animal hair or fur, your body produces a chemical called histamine. Usually histamine is a useful substance, but in an allergic reaction it causes unpleasant symptoms including itchy, watery eyes, a running or blocked nose, sneezing and skin rashes. For example, if you have a reaction to an insect bite, you may only need to take cetirizine for a day or two. You may need to take cetirizine for longer if you're taking it to prevent symptoms — for example, to stop hay fever when the pollen count is high.
Nasal eosinophilia was determined at baseline and at the end of treatment. The study was conducted in may We did not find significant differences between the two groups, except in sneezes number and sedation.
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